BADANIA NAUKOWE

Zawarty w Oligo-Elite Oligonol został poddany wielu badaniom. Badania kliniczne zostały przeprowadzone na wielu uniwersytetach, m.in.: w Japonii, Stanach Zjednoczonych, Korei, a także na Mauritius. Poniżej przedstawiamy listę publikacji naukowych.

 

1. Oligomerized lychee fruit extract (OLFE) and a mixture of vitamin C and vitamin E for endurance capacity in a double blind randomized controlled trial.

Seung Wan Kang, Sang Chul Lee, et al. (Seoul National University Hospital, Korea).

Journal of Clinical Biochemistry and Nutrition, doi:10.3164/jcbn.11-46 (2011)

 

2. Effect of Oligonol Intake on Cortisol and Cytokines, and Body Temperature after Leg Immersion into Hot Water

Young-Oh Shin, Jeong-Beom Lee, et al. (College of Medicine, Soonchunhyang University, Korea)

Food Science Biotechnology, 20(3): 659-663 (2011)

 

3. Treatment with Oligonol, a low-molecular Polyphenol derived from lychee fruit, attenuates diabetes-induced hepatic damage through regulation of oxidative stress and lipid metabolism

Jeong Sook, Chan Hum Park, Takako Yokozawa (University of Toyama)

British Journal of Nutrition, 106: 1013-1022 (2011)

 

4. Antioxidant Therapy as a Potential Approach to Severe Influenza-Associated Complications

Noboru Uchide, Hiroo Toyoda (Tokyo University of Pharmacy and Life Sciences, Japan)

Molecules, 16: 2032-2052 (2011)

 

5. Effects of Oligonol(R), an oligomerized polyphenol formulated from lychee fruit, on serum concentration and urinary excretion of uric acid

森脇優司ら(兵庫医科大学)

Journal of Functional Foods, 3, 13-16 (2011)

 

6. Supplementation with a Flavanol-rich Lychee Fruit Extract Influences the Inflammatory Status of Young Athletes

西澤幹雄、伊坂忠雄ら(立命館大学)

Phytotherapy Research (2011)

 

7. Comparison of the Effect of Oligonol, A New Lychee Fruit-derived Low Molecular Form of Polyphenol, and Epigallocatechin-3-gallate on Lipolysis in Rat Primary Adipocytes

小笠原準悦、大野秀樹ら(杏林大学医学部衛生学公衆衛生学教室)

Phytotherapy Research, DOI: 10.1002/ptr.3296 (2010)

 

8. Oligonol, an oligomerized lychee fruit-derived polyphenol, activates the Ras/ Raf-1/ MEK1/2 cascade independent of the IL-6 signaling pathway in rat primary adipocytes

小笠原準悦、大野秀樹ら(杏林大学医学部衛生学公衆衛生学教室)

Biochemical and Biophysical Research Communications, 402, 554-559 (2010)

 

9. The effect of Oligonol intake on cortisol and related cytokines in healthy young men

Jeong-Beom Lee, Hun-Mo Yanga, et al.(Soonchunhyang University, Korea)

Nutrition Research and Practice, 4(3): 203-207 (2010)

 

10. Hypolipidaemic and antioxidative effects of oligonol, a low-molecular-weight polyphenol derivedfrom lychee fruit, on renal damage in type 2 diabetic mice

横澤隆子ら(富山大学和漢医薬学総合研究所)

British Journal of Nutrition, 104(8): 1120-1128 (2010)

 

11. Oligonol a low molecular weight polyphenol of lychee fruit extract inhibits proliferation of influenza virus by blocking reactive oxygen species-dependent ERK phosphorylation

Mehran Haidari, et al.(The University of Texas Health Science Center at Houston, USA)

Phytomedicine, 17(13): 1047-1056 (2010)

 

12. Bioactivity of a flavanol-rich lychee fruit extract in adipocytes and its effects on oxidant defense and indices of metabolic syndrome in animal models

Carl L. Keen, Robert M. Hackman, et al. (University of California, Davis, USA)

Phytotherapy Research, 24: 1223-1228 (2010)

 

13. Beneficial effect of the oligomerized polyphenol oligonol on high glucose-induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells

Hiroki Yokoo, Yuichi Hattori, et al. (University of Toyama)

British Journal of Pharmacology, 159: 928-938 (2010)

 

14. Oligomerized grape seed polyphenols attenuate inflammatory changes due to antioxidative properties in coculture of adipocytes and macrophages

大野秀樹、櫻井拓也ら(杏林大学医学部衛生学公衆衛生学教室)

Journal of Nuritional Biochemistry, 21: 47-54 (2010)

 

15. Oligonol, a new lychee fruit-derived low-molecular form of polyphenol, enhances lipolysis in primary rat adipocytes through activation of the ERK1/2 pathway

小笠原準悦、大野秀樹ら (杏林大学)

Phytotherapy Research, 23: 1043-1046 (2009)

 

16. Inhibition of Lung Metastasis in Mice by Oligonol

Sung-Jae Lee, Hyung-In Moon, et al. (Wonkwang University, Korea)

Phytotherapy Research, 23: 1043-1046 (2009)

 

17. Preventive Effects of Oligomerized Polyphenol on Estradiol-Induced Prostatitis in Rats

Dong Suk Kim, Sung Joon Hong, et al. (Yonsei University College of Medicine, Seoul, Korea)

Yonsei Medical Journal, 50(3): 391-398 (2009)

 

18. Oligonol, a lychee fruit-derived low molecular weight polyphenol formulation, inhibits UVB-induced cyclooxygenase-2 expression, and induces NAD(P)H:quinone oxidoreductase-1 expression in hairless mouse skin

Joydeb Kumar Kundu, Young-Joon Surh, et al. (Seoul National University, Korea)

Journal of Functional Foods, 1(1): 98-108 (2009)

 

19. Inhibitory effects of oligonol on phorbol ester-induced tumor promotion and COX-2 expression in mouse skin: NF-κB and C/EBP as potential targets

Joydeb Kumar Kundu, Young-Joon Surh, et al. (Seoul National University, Korea)

Cancer Letters, 273: 86-97 (2008)

 

20. Acute, subchronic and genotoxicity studies conducted with Oligonol, an oligomerized polyphenol formulated from lychee and green tea extracts

大野秀樹、櫻井拓也ら(杏林大学医学部衛生学公衆衛生学教室)

Advances in Exercise and Sports Physiology, 13(4): 93-99 (2008)

 

21. Anti oxidative effects of a new lychee fruitderived polyphenol mixture, Oligonol, converted into a low-molecular form in adipocytes

櫻井拓也、大野秀樹ら(杏林大学医学部衛生学公衆衛生学教室)

Biosci Biotechnol Biochem, 72(2): 463-476 (2008)

 

22. Oligonol Inhibits UVB-induced COX-2 Expression in HR-1 Hairless Mouse Skin--P-1 and C/EBP as Potential Upstream Targets

Joydeb Kumar Kundu, Young-Joon Surh, et al. (National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Korea)

Photochemistry and Photobiology, 84: 399-406 (2008)

 

23. Flavanols: digestion, absorption and bioactivity

Robert M. Hackman, Carl L. Keen, et al. (University of California, Davis, USA)

Phytochemistry Reviews, 7: 195-208 (2008)

 

24. Platelet Reactivity in Male Smokers Following the Acute Consumption of a Flavanol-Rich Grapeseed Extract

Carl L. Keen, Robert M. Hackman, et al. (University of California, Davis, USA)

Jounal of Medicinal Food, 10(4): 725-730 (2007)

 

25. Modulation of infection-induced inflammation and locomotive deficit and longevity in senescence-accelerated mice-prone (SAMP8) model by the oligomerized polyphenol Oligonol

Koji Tomobe(Amino Up Chemical Co., Ltd.), Okeizie I. Aruoma (Touro College of Pharmacy, USA), et al.

Biomedicine & Pharmacotherapy, 61: 427-434 (2007)

 

26. Preparation, Characterization, and Antioxidative Effects of Oligomeric Proanthocyanidin-L-Cysteine Complexes

Hajime Fujii (Amino Up Chemical Co., Ltd.), Gen-ichiro Nonaka (Usaien Pharmaceutical Co., Ltd.), et al.

Jounal of Agricultural and Food Chemistry, 55: 1525-1531 (2007)

 

27. Evaluation of the safety and toxicity of the oligomerized polyphenol Oligonol

Hajime Fujii, Buxiang Sun (Amino Up Chemical Co., Ltd.), Okezie I. Aruoma (London South bank University, UK), et al.

Food and Chemical Toxicology, 45: 378-387 (2007)

 

28. Protective effect of grape seed polyphenols against high glucose-induced oxidative stress

Hajime Fujii (Amino Up Chemical Co., Ltd.), Gen-ichiro Nonaka (Usaien Pharmaceutical Co., Ltd.), et al.

Biosci Biotechnol Biochem, 70(9): 2104-11 (2006)

 

29. Low molecular proanthocyanidin dietary biofactor Oligonol: Its modulation of oxidative stress, bioefficacy, neuroprotection, food application and chemoprevention potentials

Okezie I. Aruoma (London South bank University, UK), Vidushi S. Neergheen, Theeshan Bahorun (University of Mauritius, Republic of Mauritius), et al.

Bio Factors, 27(1-4): 245-265 (2006)

 

30. Comparative efficacy of Oligonol, catechin and (-)-epigallocatechin 3-O-gallate in modulating the potassium bromate-induced renal toxicity in rats

Hiroshi Nishioka, Hajime Fujii, Buxiang Sun (Amino Up Chemical Co., Ltd.), Okezie I. Aruoma (London South bank University, UK)

Toxicology, 226: 181-187 (2006)

 

31. Protective Effects of Oligonomers og Grape Seed Polyphenols Against b-Anyloid-Induced Oxidative Cell Death

Mei-Hua Li, Young-Joon Surh (Seoul National University, Korea)

Annals of the New York Academy of Sciences, 1030: 317-329 (2004)